Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Successful treatment of invasive pulmonary aspergillosis with G-CSF and M-CSF during long-term bone marrow suppression in hypoplastic leukemia
Kazuhiro NISHIIHidetsugu MITANIHiroyuki MIYASHITANatsuki HOSHINOEiji USUIMiho SAKAKURAHiroyoshi NISHIKAWANaoyuki KATAYAMATohru KOBAYASHIHiroshi SHIKU
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2002 Volume 43 Issue 3 Pages 189-193

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Abstract
A 52-year-old man was admitted for treatment of hypoplastic leukemia (M1). After induction chemotherapy with IDR and AraC, the patient developed prolonged febrile neutropenia, and a diagnosis of invasive pulmonary aspergillosis was made. We started administration of AMPH-B and G-CSF, but the patient showed no clinical improvement. M-CSF was added to the regimen, and this led to an increase in the white blood cell count with resolution of pneumonia. It is suggested that administration of M-CSF with antibiotics and G-CSF may be beneficial for treating acute leukemia patients with prolonged febrile neutropenia after intensive chemotherapy.
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© 2002 The Japanese Society of Hematology
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