Actinomycetologica
Online ISSN : 1881-6371
Print ISSN : 0914-5818
ISSN-L : 0914-5818
Proceedings of the Workshop Micro Alchemists, “Actinomycetes”
Brasilicardin A; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis
Hisayuki KomakiAkira NemotoYasushi TanakaKatsukiyo YazawaTakashi TojoHiroaki TakagiKiyoshi KadowakiYuzuru MikamiHideyuki ShigemoriJun-ichi Kobayashi
Author information
JOURNAL FREE ACCESS

1998 Volume 12 Issue 2 Pages 92-96

Details
Abstract

Our recent search for bioactive compounds from pathogenic Nocardia resulted in the isolation of a new antibiotic, brasilicardin A, from Nocardia brasiliensis IFM 0406, a clinical isolate from a lung nocardiosis patient. Brasilicardin A is a novel tricyclic diterpenoid containing an amino acid moiety, 3-hydroxybenzoate, a rhamnose and an N-acetylglucosamine unit. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC50 value was 0.057 μg/ml. Its immunosuppressive mechanism was considered to be different from that of the reference drug, cyclosporin A (CyA), because brasilicardin A has no inhibitory activity against IL-2 production in mouse MLR assay. Also new bioactive substances which were recently isolated by our research groups from pathogenic Nocardia are reviewed.

Content from these authors
© 1998 The Society for Actinomycetes Japan
Previous article Next article
feedback
Top