2010 Volume 62 Issue 4 Pages 340-344
Estrogen-producing tumors usually originate from the ovarian matrix. We present a rare case of uterine tumor resembling ovarian sex-cord stromal tumor. A 59-year-old woman presented with postmenopausal bleeding. Magnetic resonance imaging revealed endometrial thickening and a 45-mm mass right of the uterus. The patient's serum estrogen level was slightly elevated. Therefore, we suspected ovarian sex-cord stromal tumor, and total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The tumor was found to be surrounded by myometrium. Therefore, we diagnosed uterine tumor resembling ovarian sex-cord stromal tumor type II. Uterine tumors resembling ovarian sex-cord stromal tumor were reported by Clement and Scully in 1976, who classified them into 2 types. Type I tumors are endometrial stromal tumors that show focal epithelial-like differentiation similar to that seen in ovarian sex-cord tumors. Type II tumors are uterine mural masses with predominant or exclusive histological appearance of sex-cord elements. Although type I and type II tumors have a similar presentation, the clinical behavior of these tumors differs. In type I tumors, the prognosis depends on the type, grade, and stage of the underlying stromal neoplasm. In contrast, type II tumors usually have a benign clinical course. The precise histological diagnosis is important, and the immunostaining may be useful for diagnosis. [Adv Obstet Gynecol,62 (4) : 340-344, 2010 (H22.11)]
