Small dense LDL is oxidized easily compared with LDL of the large particle diameter. Small dense LDL gave strongly rise to cause arteriosclerosis. Usually, human serum is ultra-centrifuged to measure the size of LDL particle, and the obtained LDL fraction is analyzed by gradient gel electrophoresis (GGE). The GGE method is very difficult in clinical laboratory. However, the method of using Lipophor can be done very handily. The separation analysis of the lipoprotein by the electrophoretic method which uses PAG will be expected of a clinical application as a risk factor of various diseases including arteriosclerosis with degenerated LDL which makes small dense LDL and oxidized LDL. A relative mobility for the LDL fraction showed the tendency to long in patient's serum of high concentration of triglyceride and Apo B. In each case with hyperlipidemia, diabetes, cardiac infarction, arteriosclerosis, cerebral infarction, and angina, abnormal rate of RM value admitted high to be tended intentionally compared with the healthy person group. The RM value especially tended to high for IIb and IV type of hyperlipidemia. As for the relation of mobility (RM) by the electrophoretic method compared with LDL-Chol/LDL-apoB which had been used as an index of small dense LDL for the LDL fraction, the relation of the reverse-correlation was admitted. Therefore, the method by the electrophoretic method of small dense LDL is very clinical usefull.
