抄録
The influence of the Sodium Lauryl Sulfate (SLS) upon the skin has been investigated. The occuring roughness and inflammatory reaction depend on the SLS concentrations and contact time,
In vivo experiments; the inner surface of normal human forearm was treated with 0, 0.5 and 5% of SLS solutions at 37°C for 10 minutes a day. This test was carried out daily for two successive days. Roughness (dryness and scaling) and inflammatory reaction (erythema, edema and so on) of the skin were odserved at 24 hours after original treatment with 5% of SLS solution but not observed with 0 and 0.5% of SLS solutions. The amounts of solubilized protein and the number of removed corneocytes from the skin were increased remarkably by the 5% of SLS solution.
In vitro experiments; keratin powder isolated from human heel was incubated in 0, 0.05, 0.5 and 5% of SLS solution at 37°C for 20 and 120 minutes. The amounts of solubilized protein from keratin powder, adsorbed SLS on keratin powder and SH groups of keratin powder, were increased remarkably by treatments of 5% SLS solution for 120 minutes. The hygroscopicity of keratin powder was decreased most by the treatment of 5% of SLS solution for 20 minutes.
