1993 年 27 巻 3 号 p. 383-393
To study the basic mechanism of dry skin formation and its relationship with the state of stratum corneum, the rate of stratum corneum turnover and the time required for completing the turnover were measured. This was accomplished by observing the process of declining intensity of fluorescence by dansyl chloride dyed on skin surface.
The investigaion revealed a positive correlation between dry skin condition and the distribution of turnover speeds for corneocytes in the stratum corneum. When the skin was dry and scaly, the turnover speeds tended to show a wide distribution. For a healthy, smooth skin, the turnover speeds always showed narrower distribution, indicating that all corneocytes were being renewed at a nearly constant rate. When the dry skin condition improved after a treatment, the distribution also became narrower. Contrary to common belief, the time required for stratum corneum turnover was found to have little relationship with the condition of dry skin.
Extensive screening of many active substances resulted in a discovery of a phytosterol glycoside, which was found effective in regulating and normalizing turnover speeds and improving dry skin. Clinical tests using an O/W cream containing this substance proved its effectiveness in treating dry skin.