インフルエンザウイルズ単クローン抗体難中和性 variant のマウスに対する感染
1988 年 32 巻 3 号 p. 116-120
詳細
1988 年 32 巻 3 号 p. 116-120
Three types of influenza viruses: A/NWS(H1N1), A/Kumamoto/37/79(H1N1) and A/Bangkok/1/79(H3N2) were examined for mice infected by inoculating through the nose. The A/Kumamoto strain failed to infect the mice. The mice showed neither a decrease in weight nor produced the virus antibody. On the other hand, the A/Bangkok and A/NWS strains caused a decrease in weight and the growth of virus in the organs. Especially, the A/NWS strain showed a strong virulence accompanied by a rapid decrease in weight with a high mortality rate. Ten monoclonal variants derived from the A/NWS strain were investigated by inoculating through the brain of the mice. Totally, 39(63%) of 62 mice were survived for more than 10 days after the brain inoculation. By contrast, the wild NWS strain killed all of 12 mice inoculated through the brain. The mice that survived in spite of the variant inoculation had a strong infective defense immunity and was able to withstand the wild NWS strain. Therefore, such a variant may be possile to use as an influenza vaccine.
