Establishment and application of methods for direct and rapid cell-to-cell binding

Abstract

A method for direct cell-to-cell binding has high potential to make reconstituted tissues and organs for pharmacological applications and regenerative medicine. It may be possible to produce unique materials and devices, which are based on biological properties by arranging cells appropriately. In addition, an ambitious study might lead to the construction of “multicellular artificial life” by assembling single cells. In this report we show a technology to attach cells to each other rapidly to make heterogeneous multicellular spheroids and minutely arranged cell-based micro tissues.