Mathematical modeling study on hematopoietic stem cells

Abstract

    We review recent progress in mathematical study on hematopoietic stem cells. This review paper deals with theoretical investigations for two major issues on basic and clinical hematology: “disorder of homeostasis in hematopoiesis” and “transplantation of hematopoietic stem cells”. Several mathematical models are introduced to describe self-renewal and differentiation of hematopoietic stem cells. Finally, future potential applications of mathematical study to regenerative medicine and cancer treatment are discussed.