Solvent Extraction Research and Development, Japan
Online ISSN : 2188-4765
Print ISSN : 1341-7215
ISSN-L : 1341-7215
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Use Liposome as a Designable Platform for Molecular Recognition ~ from “Statistical Separation” to “Recognitive Separation” ~
Hiroshi UMAKOSHIKeishi SUGA
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JOURNALS FREE ACCESS

2013 Volume 20 Pages 1-13

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Abstract

A liposome membrane system attracts much interest for its use as a “designable” interface for the recognition of various biomolecules because it can provide a hydrophobic nano-environment in aqueous solution and can also induce a dynamic nature in response to the variation of its environment. The methods to characterize the membrane properties of liposome have been reviewed, focusing on the micro-phase separation of different lipids on the membrane and, also, nano-domain formation there. A possible design of the liposome membrane for the recognition of biomacromolecules was discussed based on the characterized properties, by employing the RNA molecule as a case study. Finally, a possible extension of the above-described strategy toward “recognitive separation” is discussed as a future possibility.

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© 2013 Japan Association of Solvent Extraction
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