The Japanese Journal of Conservative Dentistry
Online ISSN : 2188-0808
Print ISSN : 0387-2343
ISSN-L : 0387-2343
Original Articles
Effect of Gel-type Desensitizer Containing Copolymer and Sodium Fluoride on Active Root Caries-like Lesions in Vitro
NAKANO TakafumiKAWAMURA KazuakiSHIIYA ToruYAMAMOTO TatsuoMUKAI Yoshiharu
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2022 Volume 65 Issue 3 Pages 215-220

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Abstract

 Purpose: This study used transverse microradiography (TMR) to investigate changes in active root caries-like lesions following the application of a gel-type desensitizer containing copolymer and sodium fluoride with different application times.

 Materials and Methods: Acid-resistant varnish was applied to the surface of 48 bovine root dentin samples, except over 2×3 mm test areas. These samples were immersed in demineralization solution (1.5 mM CaCl2, 0.9 mM KH2PO4, 50 mM acetic acid, 0.2 ppmF, pH 5.0) at 37°C for 24 h to make baseline lesions. The samples in the Control group were immersed in deionized water for 30 s, and those in the 30 s-Tr and 5 min-Tr groups were treated with a MS Coat Hys Block Gel containing fluoride for 30 s and 5 min, respectively. Then, the samples of these three groups were further immersed in the demineralization solution for 96 h at 37°C. Thin sections from samples in all groups were analyzed by TMR for demineralization depth and mineral loss. Statistical analysis was performed using the Kruskal-Wallis test and the Steel-Dwass multiple comparison test at a significance level of 5%.

 Results: The mineral profile of the 5 min-Tr group showed a remarkably higher mineral density compared to the Control and 30 s-Tr groups, and particularly the surface layer vol% of the 5 min-Tr group was about 45%. The lesion depth (μm) of each group was 71.5 in the Baseline lesion group, 165.8 in the Control group, 155.7 in the 30 s-Tr group, and 100.1 in the 5 min-Tr group, and the depth of the 5 min-Tr group was significantly shallower than that of the Control and 30 s-Tr groups. Mineral loss (vol%×μm) was 2,020.0 in the Baseline lesion group, 4,727.5 in the Control group, 3,592.5 in the 30 s-Tr group, and 2,102.5 in the 5 min-Tr group, and mineral loss of the 5 min-Tr group was significantly smaller than that of the Control and 30 s-Tr groups.

 Conclusion: Five-minute treatment, which is longer than the manufacturer’s recommendation of 30 s, by MS Coat Hys Block Gel effectively stopped the progression of active root caries-like lesions.

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© 2022 The Japanese Journal of Conservative Dentistry
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