5 視床髄板内核侵害受容ニューロン活動に及ぼすモルヒネの抑制作用について (第434回 大阪歯科学会例会)

抄録

We electrically stimulated the peripheral nerve and midbrain reticular formation (MRF) in the cat and recorded the response of the nociceptive neurons in the intralaminar nuclei of the thalamus. We also investigated the effects of intravenous administration of morphine on the responses obtained from these neurons. Morphine inhibited the late responses elicited by electrical stimulation of the peripheral nerve. As well, it inhibited the early responses elicited by electrical stimulation of the MRF. Administration of naloxone and cholecystokinin partially reversed these inhibitory effects of morphine. These date suggest that morphine acts at the supraspinal level.