A case of multiple neuroendocrine tumors with primary origin in bilateral mammary glands

Abstract

【Introduction】 Breast neuroendocrine tumors can manifest in various organs of the body, but those with primary origin in mammary glands are rare.　Here, we report a case of multiple breast neuroendocrine tumors in bilateral mammary glands.　【Case】 The patient was a 45-year-old woman with no significant medical, medication, or family history.　One year ago, she noticed a lump in her left breast and visited a local doctor.　Following thorough examination, she was initially diagnosed with bilateral breast cancer and subsequently referred to our hospital.　Breast ultrasonography at our hospital also indicated bilateral breast cancer, and needle biopsy results suggested bilateral breast neuroendocrine tumors.　Surgical intervention involved partial mastectomy with sentinel lymph node biopsy for the right breast tumor and mastectomy with axillary dissection for the left breast tumor.　Final pathological examination results confirmed bilateral breast neuroendocrine tumors based on hematoxylin and eosin staining and immunostaining.　【Conclusion】 This study reports a relatively rare case of multiple neuroendocrine tumors with primary origin in bilateral mammary glands.