The toxic effects of hydrogen peroxide on the growth rate of rats were observed for 100 days, and at the end of experiments, the organ weights, blood hematocrit values, plasma protein values and plasma catalase activities of rats administered hydrogen peroxide were compared with those of control animals. Two kinds of administration method, oral administration by catheter and feeding with diet containing hydrogen peroxide, were employed in this experiment.
In the case of oral administration by catheter, it was shown that no changes were observed at the doses of less than 3mg/day/100g body wt., although considerable changes were observed in the hematocrit values, protein values and catalase activities at the dose of 6mg/day/100g body wt.. However, in the case of feeding on diet containing hydrogen peroxide, no significant effects were observed at the all doses used in this work, less than 6mg/day.