Abstract
It has been assumed that diphenyl chloride (DC) wasthe toxic substance of“the Food Poisoning of Rice Oil”which happened at and near the northern part of Kyusyu from summer to autumn in 1968 in Japan.
The authors investigated the method of isolation and determination of DC from the animal tissues and organs by X-ray fluorescence analysis and further the content of DC in excreta and the distribution of DC in tissues and organs after oral administration of DC to rats.
During 48 hours after a single oral administration of 2ml of the rice oil containing 2, 500ppm of DC to rats, about 10% of dosed, DC was excreted in to feces but was not in urine at all.
In the case of the continuous administration of DC, after the oral administration of 2ml of the rice oil containing 2, 500ppm of DC to rats everyday during a week, DC was found most abundantly in skin, less abundantly in muscles, intestines, liver, pancreas, and lungs, but hardly in heart, genitals, spleen, blood or brain.
