清涼飲料水の衛生学的研究 (第7報)
II 合成保存料について (6) デヒドロ酢酸変化生成物の毒性と抗かび性
1971 年 12 巻 6 号 p. 520-524
詳細
1971 年 12 巻 6 号 p. 520-524
Acute toxicity and moldstatic activity for Asp. niger of transformation products of dehydroacetic acid were investigated.
And the results obtained were as follows:
1) The moldstatic activity of each compounds compared with dehydroacetic acid were found to be 1/15 of dehydroacetic acid in strength for diacetylacetone, 1/30 for 2, 6-dimethyl-4-pyrone-3-carboxylic acid, and 1/180 for 2, 6-dimethyl-4-pyrone.
2) On acute toxicity, the oral LD50 (and 95% confidence limits) in mice were found to be 1.33g/kg (1.23-1.44g/kg) for dehydroacetic acid, 2.33g/kg (2.04-2.65g/kg) for 2, 6-dimethyl-4-pyrone-3-carboxylic acid, 1.67g/kg (1.49-1.88g/kg) for 2, 6-dimethyl-4-pyrone, and 0.65g/kg (0.59-0.72g/kg) for diacetylacetone.
