The effects of perilla oil and safflower oil on embryonic and fetal development were examined in ICR mice. Female mice were fed either a perilla oil diet or a safflower oil diet from 4 weeks of age to 10 weeks of age and were mated with male mice fed a control diet at 10 weeks of age.
The results can be summarized as follows.
1) No significant differences from the control were found in the body weight gains of female mice fed either the perilla oil diet or a safflower oil diet from 4 to 10 weeks of age.
2) There was no significant difference in the delivery intervals, durations of pregnancy, still birth rates, litter sizes or body weights of newborns of the two dietary groups.
3) No retardation of ossification and no external and skeletal malformations were observed in the perilla oil diet group.
Based on these results together with those obtained with rats, we conclude that perilla oil is a safe and useful vegetable oil.