Application of Chemiluminescent Assay in Cytotoxicity Tests

Abstract

This study showed that chemiluminescent (CL) assay is superior to Giemsa staining assay or MTT reduction assay in sensitivity and rapidity for detection of the cytotoxic effects of four compounds (phenobarbital sodium, theophyllin, propranolol and thioridazine). Furthermore, HepG2 cells were found to be more suitable for CL assay than intestine 407 cells, being more susceptible to the toxicity of the four compounds.