小児耳鼻咽喉科
Online ISSN : 2186-5957
Print ISSN : 0919-5858
ISSN-L : 0919-5858
生後早期に聴力障害を発見しえた軽微な症状の先天性サイトメガロウイルス感染症
井上 成彰四條 裕正引田 満中澤 友幸岩原 正純金子 堅一郎
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2000 年 21 巻 1 号 p. 64-68

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We report two infants of inapparent congenital cytomegalovirus (CMV) infection accompanied by sensorineural hearing loss. In both patients, this impairment was bilateral and of significant magnitude.
Patient 1. A female infant was born at 35 weeks of gestation and weighed 1516 g at birth. She was in good condition. On admission, the serum IgM level was 31 mg/dl in the laboratory examination. Virological studies revealed significantly elevated anti-CMV IgM antibody titers and CMV was isolated from the urine. Maternal serological investigation revealed positivity for anti-CMV IgM antibody.
Patient 2. A male infant was born at 36 weeks of gestation and weighed 1800 g at birth. He was in good condition. Hepatosplenomegaly was noticed at 35 days after birth and anti-CMV IgM antibody was detected in the serum. CMV was isolated from the urine at 50 days after birth. Maternal serological investigation revealed negative anti-CMV IgM antibody. However, the serum of the mother was seropositive to anti-CMV IgG antibody at 32 weeks of gestation.
Recently, it was reported that the maternal seropositive rate of C MV antibody had decreased significantly in Japan, which may be responsible for the high incidence of congenital cytomegalovirus infection.
Therefore, we should establish a diagnostic procedure for congenital CMV infection to enable the discovery of congenital sensorineural hearing loss.

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