2019 Volume 34 Issue 1 Pages 63-68
A 59－year－old man presented with pruritic erythema on his head, which had not responded to oral corticosteroids, cyclosporine, or diaminodiphenyl sulfone. Erythematous cerebriform plaques were found on his whole face with leonine facies, which were accompanied by depilation of his head. Additionally, some papules were found on his neck. A biopsy specimen from his forehead lesion showed perifollicular and intrafollicular infiltrates of medium－to－large atypical lymphocytes and follicular mucinosis. Immunohistochemical stains of the atypical lymphocytes were positive for CD3 and CD4 and negative for CD8 and CD20. Southern blotting did not identify a clonal rearrangement of the T－cell receptor. Computed tomography showed multiple lymphadenopathy in his head and neck ; and therefore, we diagnosed the patient with stage IIB of folliculotropic mycosis fungoides. We started combination therapy with vorinostat and electron beam irradiation by tomotherapy. Ten months later, we stopped vorinostat because he developed cerebral infarction. Subsequently, bexarotene was administered, and he showed a partial response.[Skin Cancer (Japan) 2019 ; 34 : 63－68]
