A 72-year-old male with metastatic melanoma was administered intravenously with Cisplatin (CDDP, 60mg/m2), Dacarbazine (DTIC, 400mg/m2) and Vindesine (VDS, 2mg/ m2) every 4 weeks for threetreatments.
Responses to treatment were histopathologically assessed in excised spesimens of the skin. Tumor nests, which decreased in size after the second cycle of the chemotherapy, apppeared divided int several parts and surrounded with collagenfibers.Some tumor cells showedballooning, pyknosis and eosinophilic degeneration. These changes are tumor cells necrosis presumably induced by the chemotherapy.
The computed tomography demonstrated the pleural mass decreased in size after the third treatment.
These findings show that CDDP, DTIC and VDS therapy is effective for metastatic melanoma.