Fundamental principles and surgical procedures how to treat genital skin cancers are discussed and clinical examples are presented. What should be taken into consideration are the age, general conditon, expected prognosis and quality of life of the patients. As for the disease it self, the biological behaviour -if it is lethal or not-, progression -staging-, and the anatomical characteristics of genital region should be kept on mind at the same time. Surgical procedure consists basically of wide resection and closure of the surgical defect with skin graft, local skin flap or musculucutaneous flap.