1999 年 14 巻 2 号 p. 187-189
A case of rapidly progressing extramammary Paget's disease is reported. Immunohistochemical and fluorescent in situ hybridization analyses showed erbB-2 protein overexpression in invasive primary tumor and lymph node metastasis, the latter being associated with prominent gene amplification. These results suggest an important role of this oncogene activation in the progression of extramammary Paget's disease.