We presented a case of myelodysplastic syndrome with myelofibrosis associated with multiple skin eruptions. Examination showed leukocytosis with myeloblast, anemia, thrombocytopenia, and multilineage dysplasia in peripheral blood, myelofibrosis in a bone marrow biopsy, and hepatosplenomegaly. Asymptomatic reddish nodules appeared on the face and scalp. Histopathologic features of a skin biopsy revealed infiltration of megakaryocytes and myeloblasts in the dermis and subcutaneous adipose tissue. After three weeks' administration of cytosine arabinoside, these eruptions disappeared while blasts in peripheral blood faded away. Infiltration of megakaryocytes in the skin is a rare phenomenon exclusive of special disorders like myelofibrosis. We concluded the cutaneous eruption in this case was the specific skin lesion of myelodysplastic syndrome. [Skin Cancer (Japan) 2002; 17: 264-268]
