We report two cases of stage IV malignant melanoma with long survival. The first case was a 43-year-old man with a black tumor on his back. In September, 1992 he received wide resection and 10 courses of DAV-feron chemotherapy after the operation. In October, 1997 metastases of the right axillary and right supraclavicular lymph nodes and skin metastasis on the nape were found. He received resection of these lesions followed by 2 courses of DAC-Tam chemotherapy. He has been tumor-free for more than 57 months thereafter.
The second case was a 42-year-old man with a black tumor on his left thumb. In October, 1994 amputation of the left thumb and right axillary lymph node dissection were performed. He received 14 courses of DAV-feron chemotherapy after the operation. In April, 2000 left subclavicular lymph node metastasis was found. He received resection of metastasis and 2 courses of DAC-Tam chemotherapy. He has been tumor-free for more than 23 months thereafter. These two cases of stage IV malignant melanoma were successfully threated by DAC-Tam chemotherapy combined with surgical resection of metastasic lesions. [Skin Cancer (Japan) 2003; 18: 203-207]