Skin Cancer
Online ISSN : 1884-3549
Print ISSN : 0915-3535
ISSN-L : 0915-3535
熱傷瘢痕上に生じた悪性線維性組織球腫の1例
石井 義輝寺師 浩人倉田 荘太郎藤原 作平板見 智高安 進堀 重昭下村 剛芦沢 昭
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1992 年 7 巻 3 号 p. 316-320

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We presented a 58-year-old female with malignant fibrous histiocytoma developing in a burn scar. She had sustained thermal burn on the right side of her head when she was a baby. An atrophic scar with loss of hair had been present since that time. For the last 10 years, she had suffered from a recalcitrant ulcer in the burn scar. In 1982, the ulcer was resected and covered with a local skin flap. The histologic section showed large, atypical tumor cells with slit-like spaces among them, and extravasation of erythrocytes. A tentative diagnosis of malignant hemangioendothelioma was made. After 9 years of a disease-free period, a small ulcer recurred after minor trauma near the previous lesion. In the following 2 months, a fist-sized, easily bleeding tumor developed rapidly. Examination by CT-scan and MRI revealed the tumor destroyed cranial bone and invaded dura mater. A course of extensive radiotherapy consisting of 80Gy of 15MeV electron-beam was instituted and the tumor regressed clinically. The remaining ulcerative lesion was excised, including bone and dura underneath. The histological examination of this lesion revealed proliferaton of atypical, spindle cells in a storif orm pattern. Immunohistochemical stainings of specimens obtained before and after irradiation showed that the tumor cells were positive for α1-antichymotrypsin, while negative for factor VIII related antigen and UEA-1. Pulmonary metastases were detected in a short time. In spite of a combination chemotherapy (CYVA-DIC) and X-ray irradiation to lung lesions, the patient's condition rapidly deteriorated and she died of respiratory failure. Extensive irradiation in combination with excision may be the choice of treatments for primary lesions of malignant fibrous histiocytoma. This is the tenth case of malignant fibrous histiocytoma developing in a burn scar among Japanese.

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© 日本皮膚悪性腫瘍学会
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