ヌードマウス可移植性ヒト有棘細胞癌 (SCC株) に対するCamptothecin誘導体CPT-11の抗腫瘍効果
1992 年 7 巻 3 号 p. 404-413
詳細
1992 年 7 巻 3 号 p. 404-413
The antitumor effects of CPT-11, a derivative of camptothecin, on human squamous cell carcinoma (SCC strain) transplantable in nude mice were studied. The results indicated that CPT-11 has antitumor effects when administered either intravenously or subcutaneously. These effects were dose-dependent, and inhibitory effects continued even after completion of administration. In a histopathological examination, increased cornification and degeneration of the tumor cells (especially increased eosinophilia of the cytoplasmic element appearance of giant cells, pyknosis and disappearance of the nucleus) were observed. These findings appeared to be related to the inhibition of DNA synthesis, the main action of CPT-11. From the results of this study, it was evident that clinical application of CPT-11 should be successful in the cases of squamous cell carcinoma.
