1994 年 9 巻 2 号 p. 229-231
We investigated the concentration of 5-fluorourasil (5-FU) in the normal and tumoral tissue among eight patients (male; 6, female; 2, mean age; 64.8) with Paget's disease. Thirty minutes after completing the drip infusion of 5-FU (250mg/100ml of normal saline/hr), both normal and tumoral specimens were removed respectively. These specimens were kept under -70°C until study. The concentration of 5-FU was measured by high performance liquid chromatpgraphy. The concentration of 5-FU in the tumor was significantly higher than that in the normal (p<0.03) . The present data gave a further support that the combination chemotherapy based on 5-FU might be effective for sweat gland carcinoma including Paget's disease.