Abstract
Endothelin-1 (ET-1) is known as a most potent vasoconstrictive peptide, which released mostly from endothelial cells. Diligent researches in this field indicate that ET-1 is involved in many important processes such as development, cancer biology, and autoimmune disorders and cardiovascular diseases. The aim of this study was to investigate whether the endothelial cell specific ET-1 would influence the wound healing using endothelial cell specific ET-1 knockout mice. We observed that the skin wound healing in endothelial cell specific ET-1 knockout mice was accelerated than in wild-type (WT) littermates. Investigations of the overall regulatory mechanisms of wound healing by ET-1 may lead to a new therapeutic approach for wound cure.Skin Research, Suppl. 22: 34-38, 2015
