Abstract
Sarcoidosis is a multisystem granulomatous disorder with varying initial symptoms. We herein report a case of sarcoidosis with fever, which was diagnosed based on skin biopsy. A 51-year-old female had fever for more than one month before visiting our hospital's internal medicine department. The differential diagnosis included infection and connective tissue disease. Malignant lymphoma was also suspected because of high serum levels of soluble IL-2 receptor and swollen lymph nodes. Four months later, she was referred to us for random skin biopsies to discriminate intravascular lymphoma. Pruritic, miliary red papules were seen on her back and thighs. As the skin biopsy demonstrated noncaseating epithelioid granulomas, the diagnosis was sarcoidosis. Treatment with 20mg/day of oral prednisolone improved her fever, general fatigue, and skin lesions, and reduced serum levels of soluble IL-2 receptor. Although sarcoidosis with fever is rare, it should be considered as a cause of fever of unknown origin and any skin lesions should be carefully evaluated.Skin Research, 16: 343-346, 2017
