2018 Volume 17 Issue 6 Pages 317-323
This is a report on our experience of two cases diagnosed with erythema nodosum associated with granulomatous mastitis. Case 1 was a 39-year-old female. A painful subcutaneous induration appeared in her left breast and from the fourth day after onset, erythema accompanied by tenderness appeared on the extensor surfaces of her lower legs and elbows, so she was referred to our department. Skin histopathology based on her right lower leg erythema was found to be septal panniculitis in which lymphocyte/neutrophil inltration was observed around the dermal blood vessels and lymphocytes extended from the fat septum into the lobule. Regarding the histopathology based on the subcutaneous induration area on her left breast, a granuloma in which epithelial cells had mainly inltrated was observed, so she was diagnosed with erythema nodosum associated with granulomatous mastitis based on the clinical course. Case 2 was a 40-year-old female. Painful erythema and subcutaneous induration appeared in her left breast approximately two weeks prior to her initial visit to our department, and the day before her initial visit, erythema accompanied by pain appeared in the vicinity of the medial malleolus of her right foot. It has been reported that approximately 20% of granulomatous mastitis cases are complicated by erythema nodosum. Granulomatous mastitis should also be considered as a contributing factor to erythema nodosum. Skin Research, 17 : 317-323, 2018
