2019 Volume 18 Issue 4 Pages 226-230
A Japanese woman presented with joint pain in both ankles, diffuse skin sclerosis, general malaise,and muscle weakness. We initially diagnosed her with overlap syndrome of polymyositis and systemic sclerosis. Although we administered oral prednisolone up to 1 mg/kg a day, her serum creatinine kinase level remained high. We added tacrolimus and intravenous immunoglobulin treatment, which improved the serum creatinine kinase level and muscle weakness. Her serum precipitated 50kDa doublets by protein-immunoprecipitation assay and was positive for antiRuvBL1/2 antibody. We then diagnosed her with anti-RuvBL1/2 antibody-positive systemic sclerosis. The review of previous reports suggests that patients with systemic sclerosis with antiRuvBL1/2 antibody often require combination treatment with corticosteroids. Skin Research, 18 : 226-230, 2019
