皮膚
Online ISSN : 1884-541X
Print ISSN : 0018-1390
ISSN-L : 0018-1390
神経皮膚炎の発症機序に関する2~3の考察
主として皮膚のグリコーゲン代謝を中心として
川野 純夫
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ジャーナル フリー

1961 年 3 巻 1 号 p. 16-37

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In the consideration of the etiology of neurodermatitis, there still remains an unsolved issue which needs further clarification and also of classification.
Glycogen metabolism in the affected skin of the following dermatoses and experimental dermatitis was investigated on the assumption whether or not any biochemical difference may exists among so-called lichen type including neurodermatitis and the eczema type, i. e., atopic dermatitis, chronic eczema and nummular eczema.
In the pathogenesis of neurodematitis, it has been known that psychoneurogenic factor seemed to be involved and it is presumed that the cause may have been an imbalance of peripheral nervous system due to the neurogenic stressor acting upon the autonomic nervous system and which in turn would influence upon skin changing the reaction of capillary vessels and sweat gland as well as enzymic and other metabolic disturbances. The present investigation was to examine what possible influence the skin has upon glycogen metabolism by submitting sonic stimulation and electric stimulation to the autonomic nervous centers of rabbit.
The summarized results were as follows:
1. In neurodermatitis especially Lichen Vidal, the amount of glycogen and phosphorylase activity were increased as compared with normal, but were slighter than those in chronic eczema and nummular eczema. Histochemically, the examination revealed that PAS stain findings of the affected skins were roughly identical with glycogen quantity findings, however, there are some difference noted between neurodermatitis and various types of eczema on the distribution of the glycogen in the epiderm. As to the activity of phosphorylase and glucose-6-phoshatase, ther were no special difference respectively.
2. In rabbits, the amount of glycogen and activity of phosphorylase have increased in the tissue of croton oil dermatitis, DNCB-dermatitis and Nickel dermatitis, but no definite difference could be noted between primary irritant dermatitis and allergic reaction.
3. With the sonic stimulation (4000 cycle 90-60 phone), glycogen in the skin of guinea pig was reduced but phosphorylase activity was enhanced. These effects were suppressed with the administration of tranquilizer.
4. Glycogen metabolism in the skin of rabbit was markedly influenced by electric stimulation to the autonomic nervous centers, that is, both quantity of glycogen and phosphorylase activity were increased immediately after stimulation of B-symphathetic zone but they resumed normal level 1-3 hours after showing some fluctuation. When C-parasympathetic zone was stimulated, its effect in general was much less than sympathetic zone stimulation. There was, however, reduction in phosphorylase activity.
Although no characteristic finding could be observed in neurodermatitis in the aspect of glycogen metabolism, it is interpreted that the pathogenesis of this disease seems to be attributed to the imbalance of the central nervous system as well as the local etiologic factors.

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© 日本皮膚科学会大阪地方会
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