抄録
The distribution of subunit A of blood coagulation factor XIII (FXIIIa) and that of collagenous components were examined by the avidin-biotin-peroxidase complex (ABC) method for FXIIIa and by the method employing Sirius red F3BA, respectively, in 32 cases of radicular cysts.
Aside from the covering epithelial layer, the radicular cyst wall was composed of the following three layers: an inner granulomatous layer, an outer fibrous connective tissue layer, and an intermediate layer. In every layer, positive reaction for FXIIIa was observed in certain connective tissue cells. These FXIIIa-positive cells were sparse in the inner granulomatous layer, while they were numerous in the outer fibrous connective tissue layer. Also in the intermediate layer, many more FXIIIa-positive cells were observed, and most of them were dendritic in shape, in contrast to the cells in the outer fibrous connective tissue layer, which were slender and spindle-shaped.
The results obtained in the present study indicate the close relationship between the distributions of FXIIIa-positive cells and of collagenous components. Such a relationship suggests that FXIIIa-positive cells play an important role in the process of fibrosis occurring in the radicular cyst wall.
