2010 Volume 25 Pages 59-62
Ursolic acid that existing widely in plants has been well known to possess a wide range of biological functions, such as anti-inflammation, anticancer activities, reducing the stress response in crowded animal model. The purpose of this study was to investigate the effect of compression stockings coated with ursolic acid microcapsules on reduction of occupational stress among nurses. Subjects were 3 nurses working at the Mie University Hospital. Each nurse wore stockings coated with (UA) or without (Control) ursolic acid microcapsules during work. Salivary cortisol was measured before work, before lunch and after work. Analysis of variance showed significant interaction between the collection time for cortisol and with or without microcapsules (p<0.020). The cortisol levels in after work was significantly lower in UA than control (p<0.014). These results suggest that wearing of compression stockings coated with ursolic acid microcapsules during work is may reduce occupational stress.