1970 年 36 巻 12 号 p. 1214-1218
Blood sugar, glucose tolerance, urinary glucose and keton bodies, and blood pH were studied on 177 Sekoke carp and 179 normal controls.
1. Fasting blood sugar value for 106 normal carp was 39.2±0.8mg/100ml (Mean±S.E.). On the other hand, almost all the diseased carp examined showed hyperglycemia, at a fasting level of 77.6±3.6mg/100 ml (n=61).
2. Oral administration of glucose (0.5g/kg) on normal carp evoked a hyperglycemia showing a maximum after one hour and returning to near normal levels 5-6 hours after glucose loading.
3. Sekoke carp apparently showed a decreased glucose tolerance. A mode of their glucose tolerance curve was very similar to those ever described for diabetes mellitus in man and other animals.
4. Occurrence of glycosuria and ketonuria were rare in the normal controls, but they were frequently detected in the diseased carp.
5. About half the diseased carp examined showed acidotic states.