1975 Volume 41 Issue 9 Pages 965-972
The effects of pork insulin injection on eel carbohydrate metabolism were studied. A single injection of 5IU/kg of insulin produced an immediate and pronounced hypoglycemia. Blood glucose returned to a near normal level around 15 hr after the injection, but decreased slightly again thereafter. Single or repeated injections of insulin at a dose of 5IU/kg/22 hr produced a pronounced hypoglycemia and a marked decrease of plasma amino nitrogen and liver glycogen. Neither single nor repeated injections of insulin produced any significant changes in the amounts of muscle glycogen and liver fat or in the activities of liver GOT, liver GPT, liver FDP, and liver PFK.
From these results, insulin seems to accelerate the movement of amino acids from plasma to peripheral tissue space, resulting in the suppression of amino acid gluconeo-genesis in the liver of eels.