Carp were fed a diet containing 250ppm of PCB (Aroclor 1248). The effects of Aroclor 1248 on the composition and enzyme activities in serum were investigated in the carp. The results obtained were as follows:
Serum glucose content increased significantly after Aroclor 1248 ingestion. Increased globulin content accounted for increased total protein content.
Aroclor 1248 administration resulted in significant increases in the activities of various serum enzymes such as β-glucuronidase, isocitrate dehydrogenase, lactate dehydrogenase, glucose-6-phosphatase, aspartate aminotransferase, alkaline phosphatase, leucine aminopeptidase and α-hydroxybutyrate dehydrogenase in the carp. Changes in alanine aminotransferase and cholinesterase activities after ingesting Aroclor 1248, were however not significant.
Carp ingesting Aroclor 1248 showed a significant decrease in both lysosomal and micro-somal β-glucuronidase in the hepatopancreas.