Hygienic Studies on Exposure Experiments of Laboratory Animals to Air Pollutants

Report 2 Histopathological Changes of Brain Tissues and Urinary Excretion of Coporporphyrin of Rats Exposed to Carbon Monoxide

Abstract

On the rats exposed to 500ppm carbon monoxide for 1 week, the congestion of brain tissue and degeneration of Betz cells or Purkinje cells were found. These findings were not shown on the rats 1 month after the discontinuance of the exposure. The difference of the amount on the urinary excretion of coproporphyrin between exposed rats and control was not clear.
On the rats exposed to 100 ppm carbon monoxide for 22-45 days, the slight alterations such as congestion of brain tissue and degeneration of nerve cells were found. On the rats exposed to 30 ppm carbon monoxide for 22-45 days, there was shown no more than the slight swelling of brain tissue.