Abstract
A case of 65-year-old man admitted our Hospital complaining with fever and diagnosed as common bile duct stone. He had undergone cholecystoduodenostomy for cholecytolithiasis 30 years ago.
Cholecystectomy, partial resection of the duodenum, choledochotomy and T drainage were done. Histologically, mucosal dysplasia of the gallbladder was detected. Immunohistochemically, MIB-1 positive rate was 38%, and p53 protein over expression was also detected in this lesion.
In the case of cholecystoduodenostomy, chemical stimulation caused acceleration of cell cycle in gallbladder mucosa and contribute the development of dysplasia of the gallbladder. Tumor suppressor gene p53 is supposed to play an important role in pathogenesis of mucosal dysplasia of the gallbladder.
