8 ニガキ中のクアシノイド配糖体

抄録

1) Seven novel quassinoid glycosides named picrasinoside-A(4), -B(5), -C(6), -D(7), -E(8), -F(9), and -G(10) have been isolated from the barks of Picrasma ailanthoides PLANCHON, and their structures were established from spectral evidences, enzyme hydrolysis, chemical transformations into known compounds, and/or interconversion reactions. 2) Sugar linkage of each glucoside was revealed to be β-linkage by the way of coupling constant of each anomeric proton and/or enzyme hydrolysis using (β-glucosidase. 3) Configulation of β-D-glucose moiety in each glucoside except picrasinoside-A was confirmed as α-linkage from the coupling constant or half width of each acetal proton. 4) Picrasinoside-A and -B showed weak antitumor activity against P-388 lymphocytic leukemia cells in vitro, although the aglycon of picrasinoside-A showed a significant clastogenic activity in cell cultures of Don lung cells of Chinese hamster. Antileukemic activity test of the other glucosides is in progress.