23 Picrasma javanicaのクアシノイドについて(ポスター発表の部)

抄録

Quassinoids, bitter principles of Simaroubaceae plants have been extensively investigated from the interest in structure determination and their useful biological activities. Particulary, the recent studies of this family have received renewed attention because of antimalarial and antitumor activities shown by some quassinoids. In previously, we have reported the isolation and determination of ten novel des-4-methylated picrasane type quassinoids, named javanicins A-J and quassinoids glucosides, named javanicinosides A-C, from the barks, leaves and woods of Indonesian Picrasma javanica B1. further investigation led to the isolation of nine new same type quassinoids, named javanicins K, L, N, O, P, Q, R, S and T along with known quassinoids, quassin, neoquassin, nigakilactones B, F and G, isolated from the leaves and woods of the same plant. In conclusion, about 150 quassinoids have so far been isolated from Simaroubaceae plants. Although the number and the positions of methyl groups are the same on their basic skeletons and all quassinoids so far known have a methyl group at C-4, these javanicins and javanicinosides lack the methyl group at C-4. Most of the numerous quassinoids known have the C 20 basic skeleton, our study is the first report on the isolation and structure determination of the des-4-methylated quassinoids.