S-5 触媒的不斉炭素-炭素結合を機軸とする天然物の全合成(記念講演要旨)

抄録

We have been involved in design of asymmetric catalysts. development of catalytic asymmetric reactions and their application of the synthesis of bioactive molecules. In this presentation, development to catalytic asymmetric carbon-carbon bond-forming reactions and their application to the synthesis of natural products are mainly discussed. 1) We developed a very practical catalytic asymmetric Michael reaction using enones and malonates. Using this reaction as a key step, we achieved a catalytic asymmetric synthesis of strychnine 9. 2) We also developed an efficient catalytic asymmetric cyanosilylation of ketones. This reaction made possible a catalytic asymmetric synthesis of camptothecin 15 as well as fostriecin 33. In addition to these catalytic asymmetric syntheses, we also achieved catalytic asymmetric syntheses of epothilones 34, lactacystin 35, aeruginosin 298-A 36 and cylindricine C 37.