天然有機化合物討論会講演要旨集
Online ISSN : 2433-1856
第59回天然有機化合物討論会実行委員会
会議情報

19 糸状菌ポリケタイド合成酵素によるイミド含有天然物の生合成 (口頭発表の部)
*佐藤 道大Dander Jacob E.Garg Neil K.Tang Yi渡辺 賢二
著者情報
会議録・要旨集 オープンアクセス

p. 109-114

詳細
抄録

Fungal polyketides, synthesized by iterative polyketide synthases (IPKSs), comprise a structurally diverse family of natural products, displaying a wide range of biological activities. Nature can increase the structural diversity of polyketides by collaboratively pairing IPKSs in the same biosynthetic pathway. Collaborative IPKSs are frequently colocalized in the same biosynthetic gene cluster, a genetic feature that can be utilized in the genome mining of new natural products. One strategy to install nitrogen-containing functional groups in fungal polyketides is through the action of hybrid megasynthases known as PKS-NRPSs. The cis-acting NRPS module can amidate the completed polyketide acyl chain with a specific amino acid selected by the adenylation domain. The aminoacyl polyketide can then be cyclized into compounds that contain a nitrogen heterocycle, such as tetramate. Hence, one would expect pairing a PKS-NRPS with other IPKSs can lead to additional structural diversity. Here we demonstrate a new mode of collaboration between an HRPKS and a PKS-NRPS, in which the HRPKS is responsible for the biosynthesis of free, unnatural amino acid that is subsequently incorporated by the PKS-NRPS to generate new succinimide and maleimide containing natural products.

著者関連情報
© 2017 天然有機化合物討論会電子化委員会
前の記事 次の記事
feedback
Top