天然有機化合物討論会講演要旨集
Online ISSN : 2433-1856
第59回天然有機化合物討論会実行委員会
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30 NMR 併用結晶スポンジ法:未知化合物構造解析の新しいワークフロー (口頭発表の部)
*李 鐘光Roland Kersten岩井 隆宏和田 直樹Jing-Ke Weng藤田 誠
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会議録・要旨集 オープンアクセス

p. 175-182

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Structure elucidation of natural products is a still challenging field because of their scarcity that prevents chemists from fully accessing to analytical experiments especially to X-ray diffraction analysis. In 2013, we reported an X-ray technique, the crystalline sponge method, that does not require the crystallization of samples. Here, we introduce our recent results on the absolute configuration determination of noncrystalline natural products using the NMR-coupled crystalline sponge method. Combining ‘de novo’ information of XRD study with that of NMR study resulted in elucidating the complete structure of an unknown natural product much faster and more reliably than conventional tandem studies. We also show the structure determination of a major component in crude extracts from natural source. These results are expected to accelerate a structural elucidation of natural products and provide novel scaffolds, which are useful for the natural product-derived drug discovery research.

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