Thermal Medicine(Japanese Journal of Hyperthermic Oncology)
Online ISSN : 1881-9516
Print ISSN : 0911-2529
ISSN-L : 0911-2529
Enhancement of Uptake of Magnetoliposomes by Magnetic Force and Hyperthermic Effect on Tumor
MASATAKA SUZUKIMASASHIGE SHINKAIMITSUGU YANASEAKIKO ITOHIROYUKI HONDATAKESHI KOBAYASHI
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1999 Volume 15 Issue 2 Pages 79-87

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Abstract

The effect of magnetic force on the uptake of magnetoliposomes in tumor cells was investigated. When a magnet was placed under the cell culture dish, the magnetoliposome-uptake in the tumor cells was increased markedly. In a rat subcutaneous tumor, the uptake was also enhanced by using a magnet : the uptake ratio being 70.0% of the magnetoliposomes injected, compared to just 27.4% when no magnet was used. The magnetoliposomes can act as an internal heating material. Thus, the tumor was subjected to hyperthermia by applying an alternating magnetic field. As a result, the efficiency of heating was improved, and 90% of the tumor was necrosed

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© Japanese Society for Thermal Medicine
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