1999 Volume 15 Issue 2 Pages 79-87
The effect of magnetic force on the uptake of magnetoliposomes in tumor cells was investigated. When a magnet was placed under the cell culture dish, the magnetoliposome-uptake in the tumor cells was increased markedly. In a rat subcutaneous tumor, the uptake was also enhanced by using a magnet : the uptake ratio being 70.0% of the magnetoliposomes injected, compared to just 27.4% when no magnet was used. The magnetoliposomes can act as an internal heating material. Thus, the tumor was subjected to hyperthermia by applying an alternating magnetic field. As a result, the efficiency of heating was improved, and 90% of the tumor was necrosed
