Dextran Magnetiteを用いる誘導加温による癌温熱療法の研究 (第1報)

Dextran Magnetiteの磁性体としての特性について

抄録

The concept of “INTRACELLULAR HYPERTHERMIA” is selective heating of cancer cells after administration of magnetic submicron particles. We have reported the characteristics of some kind of particles in previous paper.
In this paper, we examined properties of Dextran Magnetite (DM) in inductive field of 500 kHz. DM was used as the submicron particles in addition to iron metal, stainless steel, Fe₃O₄ and 3C. DM is 5-15 nm in diameter and 3/gFe in susceptibility. DM particles are not simple mixture of dextran and ferrate but submicron complex. The heating unit (type TY-1) was a 7 kW generator of 500 kHz with a pancake type coil of 4 turns creating electro-magnetic field. The temperature of phantom with particles was measured at the inductive field of 500 kHz.
The temperature of DM was raised predominantly rather than that of other particles at the field of 500 kHz but wasn't at the field of 13.56 MHz. The relation of DM and temperature was positive in concentration of DM aqueous sol, susceptibility of DM aqueous sol and diameter of ferrate and nagative in molecular weight of dextran.
We could to create DM for most adequate purpose. This biological approach represents a new technology for effective treatment of cancer by hyperthermia.