Dextran Magnetiteを用いる誘導加温による癌温熱療法の研究 (第2報)

特に細胞内加温法 (Intracellular Hyperthermia) による各種腫瘍細胞に対する治療効果

抄録

The concept of “INTRACELLULAR HYPERTHERMIA” is local inductive heating of cancer cells after administration of submicron particles producing magnetic excitation. These particles were taken in the cancer cells intracellularly by phagocytosis, resulting in selective destruction of cancer cells with little effect on normal cells and tissues.
We examined effects of intracellular hyperthermia on Meth-A and AH60C tumor cells and a phagocytosis of AH60C, NTF reticulum cell sarcoma and cultured human esophageal cancer cells (SGF -8a). Dextran magnetite was used as, the submicron particle. DM particles were injected in animals with tumor cells intraperitoneally or intratumorously. These animals were exposed to the external inductive field of 500 kHz for 20 min. at a temperature of more than 43 °C.
The phagocytosis of tumor cells was examined microscopically. DM particles were taken intracellularly in tumor cells at 24 hours after administration. The ILS (Increase in life span) of mice was longer in the group of DM than that of Fe₃O₄ suspension. The inhibition ratio of solid tumor of rats was better in the group of DM than control group. The survival rate of rats and mice were most evident in the each groups of 2 times of hyperthermia. DM particles were very promising in inductive heating of 500 kHz.