Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
グライコデビュー(英語)
Diversity in β-galactosidase Specificities within Bifidobacterium: Towards an Understanding of β-Galactoside Metabolism in the Gut Niche
Alexander Holm Viborg
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2015 年 27 巻 156 号 p. E9-E12

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The Bifidobacterium genus harbours several health promoting members of the gut microbiota, which display metabolic specialization by preferentially utilizing dietary or host-derived β-galactosides. To approach a deeper understanding of the β-galactoside metabolism in the gut niche, the overall study investigated the bioinformatics, biochemistry and structures of glycoside hydrolase family 42 (GH42) β-galactosidases from Bifidobacterium species associated with the human gut. GH42 β-galactosidases display a large variety of sub-specificities in accordance with the diversity and complexity of β-galactosides available in the gut. The variety of sub-specificities is evident in a phylogenetic distribution where GH42 β-galactosidases segregate according to function. The first function-structure insight in GH42 illustrates that diversity manifested in sub-specificities, correlates through subtle changes in loop regions in the near vicinity of the site of catalysis. The occurrence of, multiple GH42 β-galactosidases with diverse sub-specificities within a single Bifidobacterium strain and the distinct differences among all of them from various species, emphasizes the importance and diversity of β-galactoside metabolism in bifidobacteria.

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© 2015 FCCA(Forum: Carbohydrates Coming of Age)
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