Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
HNK-1 Carbohydrate, an Attractive Unique Glyco-Epitope
Shogo Oka
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2019 Volume 31 Issue 181 Pages SE12-SE14

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Abstract

The HNK-1 carbohydrate antigen, which recognized by a monoclonal antibody HNK-1, was originally noticed as a maker of human natural killer (HNK) cells. Subsequent studies revealed that HNK-1 carbohydrate was highly expressed in the nervous system and was commonly expressed on cell adhesion molecules belonging to the immunoglobulin superfamily. Therefore, it was suggested the involvement of HNK-1 carbohydrate in migration of neural crest cells, adhesion of neurons to glial cells, and axon outgrowth. I was interested in this epitope and investigated the biosynthetic enzymes for this epitope. I fortunately received the JSCR Young Investigator Award 1998. In this review, I illustrated a series of our studies including recent findings about the HNK-1 carbohydrate.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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